Anemia happens when other diseases interfere with the body's ability to produce healthy red blood cells or abnormally increase red blood cell breakdown or loss. Fast facts on anemia The most common symptom of all types of anemia is a feeling of fatigue and a lack of energy. Other common symptoms may include: - Paleness
- fast or irregular heartbeat
- Shortness of breath
- Chest
pain
- headaches
- Light-headedness
In mild cases, there may be few or no symptoms. Some forms of anemia can have specific symptoms: - Aplastic anemia: frequent infections, and gum and skin bleeding, fevers
- B12 or Folic acid deficiency anemia: irritability and a smooth tongue
- Hemolytic anemia: jaundice, dark colored urine, fever, and abdominal pains
- Sickle cell anemia: painful swelling of the feet and hands, fatigue, and jaundice
Causes The body needs red blood cells to survive. They carry hemoglobin, a complex protein that contains iron molecules. These
molecules carry oxygen from the lungs to the rest of the body. There are many types of anemia, and there is no single cause. It can sometimes be difficult to pinpoint the exact cause. Here is a general overview of the common causes of the three main groups of anemia: 1) Anemia caused by blood loss
The most common type of anemia—iron deficiency anemia— falls into this category. It is caused by a shortage of iron, most often through blood loss. Blood loss can be acute and rapid or chronic. Rapid blood loss can include surgery, childbirth, trauma, or a ruptured blood vessel. Chronic blood loss is most common of anemia. It can result from a bleeding stomach
ulcer, bleeding colonic polyp or cancer or similar conditions and it is very important to find the cause of the anemia. Other causes of iron deficiency anemia due to blood loss include:
- Gastrointestinal conditions, such as ulcers, hemorrhoids, cancer, or gastritis
- Use of non-steroidal anti-inflammatory (NSAIDs), such as aspirin and ibuprofen
- Menstrual bleeding
- After gastric bypass, there is little or no absorption of Iron from the gut, and young menstruating women who have gastric bypass need to get intravenous iron therapy.
2) Anemia caused by decreased production or faulty red blood cell Bone
marrow is a soft, spongy tissue found in the center of bones. It is essential for the creation of red blood cells as well as white blood cells and platelets. The bone marrow produces stem cells, which develop into red blood cells, white blood cells, and platelets. Many diseases can affect bone marrow, including leukemia, lymphoma or myeloma where too many abnormal blood cells are produced and this reduces the normal production of red blood cells. Other anemias caused by decreased or faulty red blood cells include: - Sickle cell anemia: Because of a genetic mutation red blood cells are misshapen and break down abnormally quickly. The crescent-shaped blood cells can also get stuck in smaller blood vessels, causing
painful crisis.
- Iron-deficiency anemia: Too few red blood cells are produced because not enough iron is present in the body. This can be because of a poor diet, menstruation, frequent blood donation, endurance training, certain digestive conditions, such as Crohn’s disease or Ulcerative colitis surgical removal of part of the gut for weight loss or other reasons.
- Bone marrow and stem cell problems: Aplastic anemia, for example, occurs when few or no stem cells are present.
- Thalassemia occurs when red blood cells cannot grow and mature properly because of a genetic mutation common in the Mediterranean basin (beta Thalassemia) or in South East Asia and Africa (Alpha Thalassemia)
- Vitamin deficiency
anemia: Vitamin B-12 and folate are both essential to produce red blood cells. If either is deficient, red blood cell production will be too low. Examples include megaloblastic anemia and pernicious anemia. Vitamin B12 deficiency can also affect memory loss and cognition, and is more frequent in the aging population because of poor absorption from the gut…It is important for people to have their Vitamin B12 checked by blood tests periodically, since this condition can be easily corrected.
3) Anemia caused by the destruction of red blood cells Red blood cells typically have a life span of 120 days in the bloodstream, but they can be
destroyed or removed beforehand. One type of anemia that falls into this category is autoimmune hemolytic anemia, where the body's immune system mistakenly identifies its own red blood cells as a foreign substance and attacks them. Excessive hemolysis (red blood cell breakdown) can occur for many reasons, including: - Infections
- certain drugs, for example, some antibiotics
- Snake or spider venom
- Toxins produced through advanced kidney or liver disease
- An autoimmune disease such as Lupus
- Vascular grafts and prosthetic heart valves
- Clotting disorders
- Enlargement of the spleen
Treatment Treatment will depend on the
type and cause of anemia. - Iron deficiency anemia: Iron supplements (which are available to buy OTC). However, if the condition is due to loss of blood, the bleeding must be found and stopped!
- Vitamin deficiency anemias: Treatments include dietary supplements and B-12 shots.
- Thalassemia: Treatment includes folic acid supplementation, removal of the spleen, and, sometimes, blood transfusions and bone marrow transplants.
- Anemia of chronic disease: This is anemia associated with a serious, chronic underlying condition. There are no specific treatments, and the focus is on the underlying condition.
- Aplastic anemia: The patient will require blood transfusions and most likely will require bone
marrow transplant.
- Sickle cell anemia: Treatment includes oxygen therapy, pain relief, and intravenous fluids. There may also be need for folic acid supplements, and blood transfusions. A cancer drug known as Hydrae is also used.
- Hemolytic anemias: Patients should avoid the medication that may make it worse, and they may receive immunosuppressant drugs such as Prednisone for the treatment of the anemia.
Dana Shani MD, MBA Hematology/Oncology 178 East 85th St, 4th floor NYC, NY 10028 Tel: 212 434 3630 Fax 212 434 3639 Email: dshani@northwell.edu Northwell Health Visit us at Northwell.edujewishdokshitsy.org |